bio-2-0-final-ifigure

Opportunities in Bio 2.0

The last part of my series is about the opportunities that “software eating bio” creates. Opportunities are plentiful in this brave new world. Due to the exponential advancements we’re seeing in processes, tools and cost, biotech is experiencing the same kind of dynamic as digital technology at large. All this fundamentally changes the economics of starting up in Bio 2.0.
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biology goes digital

Biology goes digital – data, processing and AI as enablers of a new kind of medicine

Computing makes leveraging the convergence of exponential technologies in healthcare possible. The major drivers are the increase in the memory capacity and processing power and the improvement of algorithms. It serves as the connecting piece between the exponential increase in data and its potential use via the exponential decrease in cost and difficulty of biologic applications through e.g. gene editing.
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PubMed papers citing CRISPR increased exponentially

CRISPR/Cas: Programming the code of life just go exponentially easier

Origins

Since the discovery of heredity, scientists were looking for ways of how to influence what traits were passed from one generation to the next. Although gene editing was possible in the past, the methods used so far were cumbersome, costly or error prone.

The discovery of a curious region in the genes of obscure bacteria over 20 years ago led to the development of the most convenient and precise instrument for gene editing so far: CRISPR. Since it’s first application in non-bacterial, or eukaryotic, cells, application of the technique increased exponentially.
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Cost per Genome

Exponential progress in sequencing and the basis of precision medicine

Cost per genome has declined exponentially

Your genome contains the information that forms you. It consists of 3.2 billion base pairs and around 22.000 genes. Knowing this code of life and understanding what it does is crucial for applications ranging from medicine to agriculture. Only when we know what the genome contains, can we use tools such as CRISPR to edit it.
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Number of bacterial and archaeal genomes sequenced each year and submitted to NCBI. Taken from Land et al. 2015 http://www.ncbi.nlm.nih.gov/pubmed/25722247

Why the convergence of several exponential technologies represents the largest opportunity of our time

Because of the convergence of several exponential technologies healthcare and life sciences are currently undergoing the transition to the next era. In the coming years we’ll see companies that will develop solutions that will make treatments more effective and safer. We’ll see rapid discovery of new cures. And we’ll see ever faster development of technology that will help us stay healthier longer as well as manage our diseases better. We’re experiencing the beginning of a Cambrian explosion in digital health.
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russian-internet-warp-speed

Runet at Warp Speed

I can’t believe at what speed the Runet has transformed. On my previous trip, just 4 years ago I remember feeling confused and disappointed by most Russian websites. Now, being the largest European Internet market, the Russian Internet has not only closed any gap but became a technology leader and boasts global players.
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mountain-data

Need a way to picture Big Data? Start working with it!

Fact: It’s super hard to imagine very large numbers. Take a moment and try to picture a mountain that is 50,000 km high, or a pile of $20 billion! Close your eyes for a moment and try to visualize that giant rock or massing mountain of $$$. And with massive amounts of bits and bytes, it’s no difference. What it means to have millions of observations to process, is just mindblowlingly tough to image a priory. But it gets so much easier once you start working with it.
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